Introduction The increasing prevalence of coexisting health conditions poses a challenge to healthcare providers and healthcare systems.Spinal pain (eg, neck and back pain) and spinal pathologies (eg, osteoporotic fractures and degenerative spinal disease) exist concurrently with other non-spinal health conditions (NSHC).However, the scope of what
Abstract Activation of the p53 tumor suppressor triggers a transcriptional program to control cellular response to stress.However, the molecular mechanisms by which p53 controls gene transcription are not completely understood.Here, we uncover the critical role of spatio-temporal genome architecture in this process.We demonstrate that p53 drives di
To meet the needs of high-power fiber lasers, a new fiber structure called chirally coupled core (CCC) fiber has attracted the attention of researchers all over the world.CCC fiber consists better waters xl7000 of two cores, one of which is a central core distributed along the axial direction, and the other is a side core that is offset from the ce